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                             April 2, 2021

       Thomas Butler
       Chief Executive Officer
       Biomea Fusion, Inc.
       726 Main Street
       Redwood City, CA 94063

                                                        Re: Biomea Fusion, Inc.
                                                            Registration
Statement on Form S-1
                                                            Filed March 26,
2021
                                                            File No. 333-254793

       Dear Mr. Butler:

                                                        We have reviewed your
registration statement and have the following comment.

              Please respond to this letter by amending your registration
statement and providing the
       requested information. If you do not believe our comment applies to your
facts and
       circumstances or do not believe an amendment is appropriate, please tell
us why in your
       response.

              After reviewing any amendment to your registration statement and
the information you
       provide in response to this comment, we may have additional comments.

       Registration Statement on Form S-1

       Prospectus Summary
       Overview, page 1

   1.                                                   We note your response
to prior comment 2 regarding the two programs in your pipeline
                                                        table on page 2 with
undisclosed targets which appear to be in the discovery phase.
                                                        Since your filing
contains minimal discussion of these two programs, it appears that these
                                                        programs are not
sufficiently material to your operations to warrant inclusion in the
                                                        pipeline table. Please
remove these two programs. We also believe that Optimization
                                                        should be depicted
under the Discovery column. A textual discussion of the program is a
                                                        more appropriate place
to make distinctions regarding different segments within a
                                                        particular phase.
Please revise accordingly.

              We remind you that the company and its management are responsible
for the accuracy
       and adequacy of their disclosures, notwithstanding any review, comments,
action or absence of
 Thomas Butler
Biomea Fusion, Inc.
April 2, 2021
Page 2

action by the staff.

       Refer to Rules 460 and 461 regarding requests for acceleration. Please
allow adequate
time for us to review any amendment prior to the requested effective date of
the registration
statement.

       You may contact Eric Atallah at 202-551-3663 or Daniel Gordon at
202-551-3486 if you
have questions regarding comments on the financial statements and related
matters. Please
contact Dillon Hagius at 202-551-7967 or Ada D. Sarmento at 202-551-3798 with
any other
questions.



                                                           Sincerely,
FirstName LastNameThomas Butler
                                                           Division of
Corporation Finance
Comapany NameBiomea Fusion, Inc.
                                                           Office of Life
Sciences
April 2, 2021 Page 2
cc:       Miles P. Jennings, Esq.
FirstName LastName