0000950170-24-052082 | 10-Q | XBRL Viewer

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Condensed Balance Sheets (Parenthetical) - $ / shares	Mar. 31, 2024	Dec. 31, 2023
Preferred stock, par value	$ 0.0001	$ 0.0001
Preferred stock, shares authorized	10,000,000	10,000,000
Preferred stock, shares issued	0	0
Preferred stock, shares outstanding	0	0
Common stock, par value	$ 0.0001	$ 0.0001
Common stock, shares authorized	300,000,000	300,000,000
Common stock, shares issued	35,933,586	35,866,610
Common stock, shares outstanding	35,933,586	35,866,610

Commitments and Contingencies	3 Months Ended
Mar. 31, 2024
Commitments and Contingencies Disclosure [Abstract]
Commitments and Contingencies	Note 8. Commitments and Contingencies Legal Proceedings The Company, from time to time, may be party to litigation arising in the ordinary course of business. The Company records a liability for such matters when it is probable that future losses will be incurred and that such losses can be reasonably estimated. Significant judgment by the Company is required to determine both probability and the estimated amount. Management is currently not aware of any legal matters that could have a material adverse effect on its financial position, results of operations or cash flows. Indemnification The Company enters into standard indemnification agreements in the ordinary course of business. Pursuant to these arrangements, the Company indemnifies, holds harmless and agrees to reimburse the indemnified parties for losses suffered or incurred by the indemnified party, in connection with any trade secret, copyright, patent or other intellectual property infringement claim by any third party with respect to its technology. The term of these indemnification agreements is generally perpetual any time after the execution of the agreement. The maximum potential amount of future payments the Company could be required to make under these arrangements is not determinable. The Company has never incurred costs to defend lawsuits or settle claims related to these indemnification agreements. As a result, the Company believes the fair value of these agreements is not material. The Company has also entered into indemnification agreements with its directors and officers that may require the Company to indemnify its directors and officers against liabilities that may arise by reason of their status or service as directors or officers to the fullest extent permitted by Delaware corporate law. The Company currently has directors’ and officers’ insurance.

Commitments and Contingencies

3 Months Ended

Mar. 31, 2024

Commitments and Contingencies Disclosure [Abstract]

Commitments and Contingencies

Note 8. Commitments and Contingencies

Legal Proceedings

The Company, from time to time, may be party to litigation arising in the ordinary course of business. The Company records a liability for such matters when it is probable that future losses will be incurred and that such losses can be reasonably estimated. Significant

judgment by the Company is required to determine both probability and the estimated amount. Management is currently not aware of any legal matters that could have a material adverse effect on its financial position, results of operations or cash flows.

Indemnification

The Company enters into standard indemnification agreements in the ordinary course of business. Pursuant to these arrangements, the Company indemnifies, holds harmless and agrees to reimburse the indemnified parties for losses suffered or incurred by the indemnified party, in connection with any trade secret, copyright, patent or other intellectual property infringement claim by any third party with respect to its technology. The term of these indemnification agreements is generally perpetual any time after the execution of the agreement. The maximum potential amount of future payments the Company could be required to make under these arrangements is not determinable. The Company has never incurred costs to defend lawsuits or settle claims related to these indemnification agreements. As a result, the Company believes the fair value of these agreements is not material.

The Company has also entered into indemnification agreements with its directors and officers that may require the Company to indemnify its directors and officers against liabilities that may arise by reason of their status or service as directors or officers to the fullest extent permitted by Delaware corporate law. The Company currently has directors’ and officers’ insurance.

Leases (Tables)

3 Months Ended

Mar. 31, 2024

Leases [Abstract]

Schedule of Lease Costs and Cash Paid

The following table summarizes the lease costs and cash paid for the Company’s leases (in thousands):


	Three Months Ended
	March 31,
	2024		2023
Cash paid for operating lease liabilities	$	640	$	840
Operating lease costs		990		980
Short-term lease cost		—		—
Variable lease costs		381		245

Schedule of Maturities of Lease Liabilities

The maturities of lease liabilities as of March 31, 2024 were as follows (in thousands):


	Operating Lease
Year Ending December 31,	Commitments
2024 (remaining nine months)	$	3,154
2025		2,903
2026		1,525
2027		1,443
2028		1,474
Thereafter		4,827
Total future undiscounted lease payments		15,326
Less: Imputed interest		(4,234	)
Total operating lease liabilities	$	11,092
Operating lease liabilities, current		3,166
Operating lease liabilities, non-current		7,926
Total operating lease liabilities	$	11,092

Schedule of Supplemental Balance Sheet Information Related to Leases

Supplemental balance sheet information related to leases was as follows:


	Three Months Ended
	March 31,
	2024			2023
Weighted-average remaining lease term (in years) - operating leases		5.9			6.1
Weighted-average discount rate - operating leases		11.42	%		11.43	%

Leases - Additional Information (Details) - USD ($) $ in Millions	1 Months Ended	3 Months Ended
	Nov. 30, 2023	Mar. 31, 2024
Lessee Lease Description [Line Items]
Reimbursement on additional lease payments		$ 0.4
Lease term annual interest rate		7.00%
Redwood City, California
Lessee Lease Description [Line Items]
Operating lease, expiration year		2025
San Carlos, California
Lessee Lease Description [Line Items]
Operating lease, expiration year		2027
Claim against tenant improvement allowance	$ 1.5

Stock-Based Compensation - Summary of Stock-Based Compensation Expense Recorded in Statements of Operations and Allocated (Details) - Equity Incentive Plan and Employee Stock Purchase Plan - USD ($) $ in Thousands	3 Months Ended
	Mar. 31, 2024	Mar. 31, 2023
Share Based Compensation Arrangement By Share Based Payment Award [Line Items]
Total stock-based compensation expense	$ 5,022	$ 3,233
Research and Development
Share Based Compensation Arrangement By Share Based Payment Award [Line Items]
Total stock-based compensation expense	2,546	1,474
General and Administrative
Share Based Compensation Arrangement By Share Based Payment Award [Line Items]
Total stock-based compensation expense	$ 2,476	$ 1,759

- Definition

Line items represent financial concepts included in a table. These concepts are used to disclose reportable information associated with domain members defined in one or many axes to the table.

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+ Details

Capital Structure - Additional Information (Details) - USD ($)	1 Months Ended
	Apr. 30, 2023	Mar. 31, 2024	Dec. 31, 2023
Class Of Stock [Line Items]
Common stock, par value		$ 0.0001	$ 0.0001
Common stock, shares authorized		300,000,000	300,000,000
Preferred stock, shares authorized		10,000,000	10,000,000
Preferred stock, par value		$ 0.0001	$ 0.0001
Dividends declared		$ 0
Net proceeds from offering	$ 161,800,000
Common Stock
Class Of Stock [Line Items]
Issuance of common stock (in shares)	5,750,000
Public offering price	$ 30
Underwritting discounts and commissions and offering costs	$ 11,000,000

Balance Sheet Components (Tables)

3 Months Ended

Mar. 31, 2024

Balance Sheet Related Disclosures [Abstract]

Property, Plant and Equipment [Table Text Block]

Property and equipment, net consists of the following (in thousands):


	March 31,			December 31,
	2024			2023
Laboratory equipment	$	3,902		$	3,852
Leasehold improvements		3,195			3,195
Computer equipment		146			130
Furniture and fixtures		409			409
Construction in progress		6			4
Total property and equipment, gross		7,658			7,590
Less: accumulated depreciation		(2,852	)		(2,431	)
Total property and equipment, net	$	4,806		$	5,159

Schedule of Accrued Liabilities [Table Text Block]

Accrued expenses and other current liabilities consisted of the following (in thousands):


	March 31,		December 31,
	2024		2023
Accrued research and development materials and services	$	14,054	$	6,952
Accrued personnel expenses		2,430		5,956
Accrued professional services		669		443
Other		226		192
Total accrued expenses and other current liabilities	$	17,379	$	13,543

Condensed Statements of Operations and Comprehensive Loss - USD ($) $ in Thousands	3 Months Ended
	Mar. 31, 2024	Mar. 31, 2023
Operating expenses:
Research and development	$ 33,776	$ 24,395
General and administrative	7,283	5,636
Total operating expenses	41,059	30,031
Loss from operations	(41,059)	(30,031)
Interest and other income, net	1,998	980
Net loss	(39,061)	(29,051)
Other comprehensive loss:
Unrealized gain (loss) on investments, net		1
Comprehensive loss	$ (39,061)	$ (29,050)
Net loss per common share, basic	$ (1.09)	$ (0.98)
Net loss per common share, diluted	$ (1.09)	$ (0.98)
Weighted-average number of common shares used to compute basic net loss per common share	35,890,370	29,586,468
Weighted-average number of common shares used to compute diluted net loss per common share	35,890,370	29,586,468

Net Loss Per Share

3 Months Ended

Mar. 31, 2024

Earnings Per Share [Abstract]

Net Loss Per Share

Note 9. Net Loss Per Share

Basic and diluted net loss per share is computed by dividing net loss by the weighted-average number of common stock outstanding for the period. For periods in which the Company generated a net loss, the Company does not include the potential impact of dilutive securities in diluted net loss per share, as the impact of these items is anti-dilutive.

The following equity instruments were excluded from the calculation of diluted net loss per share because their effect would have been anti-dilutive for the periods presented:


	March 31,
	2024		2023
Stock options, issued and outstanding		9,169,285		6,949,081
Estimated shares issuable under the employee stock purchase plan		114,511		105,062
Restricted stock, issued and outstanding		65,130		247,157
Total		9,348,926		7,301,300

Net Loss Per Share - Summary of Potential Dilutive Securities Excluded from Calculation of Diluted Per Share (Details) - shares	3 Months Ended
	Mar. 31, 2024	Mar. 31, 2023
Antidilutive Securities Excluded From Computation Of Earnings Per Share [Line Items]
Anti Dilutive Shares	9,348,926	7,301,300
Stock Options
Antidilutive Securities Excluded From Computation Of Earnings Per Share [Line Items]
Anti Dilutive Shares	9,169,285	6,949,081
Estimated Shares Issuable Under the Employee Stock Purchase Plan
Antidilutive Securities Excluded From Computation Of Earnings Per Share [Line Items]
Anti Dilutive Shares	114,511	105,062
Restricted Stock
Antidilutive Securities Excluded From Computation Of Earnings Per Share [Line Items]
Anti Dilutive Shares	65,130	247,157

Organization

3 Months Ended

Mar. 31, 2024

Organization, Consolidation and Presentation of Financial Statements [Abstract]

Organization

Note 1. Organization

Organization

Biomea Fusion, Inc., (the Company), was established in the state of Delaware in August 2017 as Biomea Fusion, LLC. In December 2020, all outstanding membership interests in Biomea Fusion, LLC were converted into equity interests in the Company. The capitalization information included in these unaudited condensed financial statements is consistently presented as if it is that of Biomea Fusion, Inc., even during the prior period when investors held their equity interests in Biomea Fusion, LLC.

The Company is a clinical-stage biopharmaceutical company dedicated to discovering and developing novel covalent small molecules to treat and improve the lives of patients with genetically defined cancers and metabolic diseases. Since its inception in 2017, the Company has built its proprietary FUSIONTM System platform to design and develop a pipeline of novel covalent product candidates.

Basis of Presentation

The accompanying unaudited condensed financial statements have been prepared in accordance with generally accepted accounting principles in the United States of America (GAAP) and applicable rules and regulations of the Securities and Exchange Commission (SEC) regarding interim financial reporting. As permitted under those rules, certain footnotes or other financial information that are normally required by GAAP have been condensed or omitted, and accordingly the balance sheet as of December 31, 2023 has been derived from the audited financial statements at that date but does not include all of the information required by GAAP for complete financial statements. These unaudited condensed financial statements have been prepared on the same basis as the Company’s annual financial statements and, in the opinion of management, reflect all adjustments, consisting only of normal recurring adjustments which are necessary for a fair statement of the Company’s financial information. The unaudited interim results of operations for the three months ended March 31, 2024 are not necessarily indicative of the results to be expected for the year ending December 31, 2024 or for any other interim period or for any other future year.

The accompanying unaudited condensed financial statements should be read in conjunction with the audited financial statements and the related notes thereto for the year ended December 31, 2023, included in the Company’s Annual Report on Form 10-K filed with the SEC on March 28, 2024.

Liquidity and Capital Resources

The Company has incurred net operating losses and negative cash flows from operations since its inception and had an accumulated deficit of $287.9 million at March 31, 2024. As of March 31, 2024, the Company had cash, cash equivalents, and restricted cash of $145.3 million. Management believes that the existing financial resources are not sufficient to continue operating activities for at least one year past the issuance date of these unaudited condensed financial statements. The Company’s ability to continue as a going concern will require the Company to raise additional capital to fund the Company's operations through public or private equity offering, debt financings, collaborations and licensing arrangements or other sources. There can be no assurance that additional financing will be available to the Company or that such financing, if available, will be available on terms acceptable to the Company. Accordingly, there is substantial doubt about the Company’s ability to continue as a going concern.

The Company has historically financed its operations primarily through the sale of convertible preferred stock and common stock and the issuance of unsecured promissory notes. To date, none of the Company’s product candidates have been approved for sale, and the Company has not generated any revenue since inception. Management expects operating losses to continue and increase for the foreseeable future, as the Company continues clinical development activities for its lead product candidate and advances the preclinical and clinical development of other product candidates. The Company’s prospects are subject to risks, expenses and uncertainties frequently encountered by companies in the biotechnology industry as discussed below. There can be no assurance that in the event the Company requires additional financing, such financing will be available on terms which are favorable or at all. Failure to generate sufficient cash flows from operations, raise additional capital or reduce certain discretionary spending would have a material adverse effect on the Company’s ability to achieve its intended business objectives.

Organization - Additional Information (Detail) - USD ($) $ in Thousands	Mar. 31, 2024	Dec. 31, 2023
Organization, Consolidation and Presentation of Financial Statements [Abstract]
Accumulated deficit	$ (287,886)	$ (248,825)
Cash, cash equivalents, and restricted cash	$ 145,300

- Definition

Amount of accumulated undistributed earnings (deficit).

+ References + Details

Leases - Schedule of Maturities of Lease Liabilities (Details) - USD ($) $ in Thousands	Mar. 31, 2024	Dec. 31, 2023
Lessee, Operating Lease, Liability, to be Paid, Fiscal Year Maturity [Abstract]
2024 (remaining nine months)	$ 3,154
2025	2,903
2026	1,525
2027	1,443
2028	1,474
Thereafter	4,827
Total future undiscounted lease payments	15,326
Less: Imputed interest	(4,234)
Total operating lease liabilities	11,092
Operating lease liabilities, current	3,166	$ 2,466
Operating lease liabilities, non-current	$ 7,926	$ 7,830

Stock-Based Compensation (Tables)

3 Months Ended

Mar. 31, 2024

Share-Based Payment Arrangement [Abstract]

Summary of Stock-Based Compensation Expense Recorded in Statements of Operations and Allocated

Total stock-based compensation expense related to the Company’s equity incentive plan and employee stock purchase plan was recorded in the statements of operations and allocated as follows (in thousands):


	Three Months Ended
	March 31,
	2024		2023
Research and development	$	2,546	$	1,474
General and administrative		2,476		1,759
Total stock-based compensation expense	$	5,022	$	3,233

Summary of Stock Option Activity

The following table summarizes stock option activity:


	Outstanding Options
	Shares			Weighted- Average Exercise		Weighted- Average Remaining Contractual Term (Years)
Balance, December 31, 2023		7,357,607		$	9.34		8.1
Granted		1,838,510			14.60
Exercised		(22,750	)		5.09
Cancelled		(4,082	)		9.61
Balance, March 31, 2024		9,169,285			10.40		8.3
Exercisable, March 31, 2024		4,020,182		$	9.08		7.6

Summary of Restricted Stock Activity

The following table summarizes the restricted stock activity:


	Number of Restricted Stock Awards			Weighted-Average Grant Date Fair Value
Balance, December 31, 2023		111,920		$	4.06
Granted		—			—
Released		(44,226	)		4.03
Forfeited		(2,564	)		3.96
Balance, March 31, 2024		65,130		$	4.09

Fair Value Measurement

3 Months Ended

Mar. 31, 2024

Fair Value Disclosures [Abstract]

Fair Value Measurement

ote 3. Fair Value Measurement

The Company measures and reports certain financial instruments as assets and liabilities at fair value on a recurring basis. The following tables set forth the fair value of the Company’s financial assets, which consist of cash equivalents and marketable securities measured and recognized at fair value (in thousands):


		March 31, 2024
	Fair Value Hierarchy Level	Amortized Cost		Gross Unrealized Gains		Gross Unrealized Losses		Fair Value
Financial assets included in cash and cash equivalents:
Money market funds	Level 1	$	142,998	$	—	$	—	$	142,998
Total		$	142,998	$	—	$	—	$	142,998


		December 31, 2023
	Fair Value Hierarchy Level	Amortized Cost		Gross Unrealized Gains		Gross Unrealized Losses		Fair Value
Financial assets included in cash and cash equivalents:
Money market funds	Level 1	$	174,429	$	—	$	—	$	174,429
Total		$	174,429	$	—	$	—	$	174,429

The Company evaluates transfers between levels at the end of each reporting period. There were no transfers between Levels 1, 2 and 3 during the three months ended March 31, 2024 and 2023. As of March 31, 2024 and December 31, 2023, there were no financial instruments classified as Level 2 or Level 3. There have been no realized gains or losses recognized for the periods presented. Unrealized gains and losses are included in accumulated other comprehensive loss within stockholders' equity on the balance sheet.

There were no investments as of March 31, 2024 and December 31, 2023, as such, no allowance for credit losses has been recognized as of March 31, 2024. During the three months ended March 31, 2024 and 2023, the Company did not recognize any impairment losses related to investments.

- Definition

The entire disclosure for the fair value of financial instruments (as defined), including financial assets and financial liabilities (collectively, as defined), and the measurements of those instruments as well as disclosures related to the fair value of non-financial assets and liabilities. Such disclosures about the financial instruments, assets, and liabilities would include: (1) the fair value of the required items together with their carrying amounts (as appropriate); (2) for items for which it is not practicable to estimate fair value, disclosure would include: (a) information pertinent to estimating fair value (including, carrying amount, effective interest rate, and maturity, and (b) the reasons why it is not practicable to estimate fair value; (3) significant concentrations of credit risk including: (a) information about the activity, region, or economic characteristics identifying a concentration, (b) the maximum amount of loss the entity is exposed to based on the gross fair value of the related item, (c) policy for requiring collateral or other security and information as to accessing such collateral or security, and (d) the nature and brief description of such collateral or security; (4) quantitative information about market risks and how such risks are managed; (5) for items measured on both a recurring and nonrecurring basis information regarding the inputs used to develop the fair value measurement; and (6) for items presented in the financial statement for which fair value measurement is elected: (a) information necessary to understand the reasons for the election, (b) discussion of the effect of fair value changes on earnings, (c) a description of [similar groups] items for which the election is made and the relation thereof to the balance sheet, the aggregate carrying value of items included in the balance sheet that are not eligible for the election; (7) all other required (as defined) and desired information.

+ References + Details

Summary of Significant Accounting Policies (Policies)

3 Months Ended

Mar. 31, 2024

Accounting Policies [Abstract]

Recent Accounting Pronouncements - Not Yet Adopted

In November 2023, the FASB issued ASU 2023-07, Improvements to Reportable Segment Disclosures (“ASU 2023-07”) which is intended to improve reportable segment disclosure requirements, primarily through additional disclosures about significant segment expenses, including for single reportable segment entities. The standard is effective for fiscal years beginning after December 15, 2023, and interim periods within fiscal years beginning after December 15, 2024, with early adoption permitted. The amendments should be applied retrospectively to all prior periods presented in the financial statements. The Company is currently evaluating the disclosure requirements related to the new standard.

In December 2023, the Financial Accounting Standards Board issued Accounting Standards Update (“ASU”) 2023-09, “Income Taxes - Improvements to Income Tax Disclosures” requiring enhancements and further transparency to certain income tax disclosures, most notably the tax rate reconciliation and income taxes paid. This ASU is effective for fiscal years beginning after December 15, 2024 on a prospective basis and retrospective application is permitted. The Company is currently evaluating the impact of the adoption of this standard on the Company’s financial statements and related disclosures.

Fair Value Measurement - Additional Information (Details) - USD ($)	3 Months Ended
	Mar. 31, 2024	Mar. 31, 2023	Dec. 31, 2023
Fair Value Assets And Liabilities Measured On Recurring And Nonrecurring Basis [Line Items]
Unrealized gains (losses) on available for sale securities	$ 0		$ 0
Fair Value	142,998,000		174,429,000
Investments	0		0
Allowance for credit Loss	0
Fair value liabilities transferred from level 1 to level 2	0	$ 0
Fair value liabilities transferred from level 2 to level 1	0	0
Fair value assets transferred from level 1 to level 2	0	0
Fair value assets transferred from level 2 to level 1	0	0
Fair value liabilities transferred to level 3	0	0
Fair value liabilities transferred from level 3	0	0
Fair value assets transferred to level 3	0	0
Fair value assets transferred from level 3	0	0
Impairment loss on investments	0	$ 0
Level 2
Fair Value Assets And Liabilities Measured On Recurring And Nonrecurring Basis [Line Items]
Fair Value	0		0
Level 3
Fair Value Assets And Liabilities Measured On Recurring And Nonrecurring Basis [Line Items]
Fair Value	$ 0		$ 0

Capital Structure

3 Months Ended

Mar. 31, 2024

Equity [Abstract]

Capital Structure

Note 6. Capital Structure

Common Stock

The Company’s amended and restated certificate of incorporation authorizes the Company to issue up to 300,000,000 shares of common stock with a par value of $0.0001 per share and 10,000,000 shares of preferred stock with a par value of $0.0001 per share.

Common stockholders are entitled to dividends when and if declared by the Company’s Board of Directors and after any preferred share dividends are fully paid. The holder of each share of common stock is entitled to one vote. As of March 31, 2024, no dividends have been declared.

Public Offering

In April 2023, pursuant to a registration statement on Form S-3, the Company issued and sold 5,750,000 shares of common stock at a public offering price of $30.00 per share in an underwritten public offering. The net proceeds to the Company from the offering were approximately $161.8 million, after deducting underwriting discounts and commissions and offering costs of approximately $11.0 million.

- Definition

The entire disclosure for equity.

+ References

Reference 1: http://www.xbrl.org/2003/role/disclosureRef
-Topic 505
-SubTopic 10
-Name Accounting Standards Codification
-Section 50
-Paragraph 13
-Subparagraph (b)
-Publisher FASB
-URI https://asc.fasb.org//1943274/2147481112/505-10-50-13

Reference 2: http://www.xbrl.org/2003/role/disclosureRef
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-Paragraph 13
-Subparagraph (h)
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-URI https://asc.fasb.org//1943274/2147481112/505-10-50-13

Reference 3: http://www.xbrl.org/2003/role/disclosureRef
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-Name Accounting Standards Codification
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-Paragraph 14
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-URI https://asc.fasb.org//1943274/2147481112/505-10-50-14

Reference 4: http://www.xbrl.org/2003/role/disclosureRef
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-Subparagraph (a)
-Publisher FASB
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Reference 5: http://www.xbrl.org/2003/role/disclosureRef
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-Name Accounting Standards Codification
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-Paragraph 2
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Reference 6: http://www.xbrl.org/2003/role/disclosureRef
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-Name Accounting Standards Codification
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-URI https://asc.fasb.org//1943274/2147481004/946-505-50-6

Reference 7: http://www.xbrl.org/2003/role/disclosureRef
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Reference 8: http://www.xbrl.org/2003/role/disclosureRef
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-Name Accounting Standards Codification
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-Paragraph 1
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Reference 9: http://www.xbrl.org/2003/role/disclosureRef
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-Paragraph 1
-Subparagraph (SX 210.4-08(e)(1))
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-Topic 505
-Name Accounting Standards Codification
-Publisher FASB
-URI https://asc.fasb.org//505/tableOfContent

Reference 11: http://www.xbrl.org/2003/role/disclosureRef
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-URI https://asc.fasb.org//1943274/2147481112/505-10-50-13

Reference 12: http://www.xbrl.org/2003/role/disclosureRef
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-URI https://asc.fasb.org//1943274/2147481112/505-10-50-13

Reference 13: http://www.xbrl.org/2003/role/disclosureRef
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-Paragraph 13
-Subparagraph (i)
-Publisher FASB
-URI https://asc.fasb.org//1943274/2147481112/505-10-50-13

Reference 14: http://www.xbrl.org/2003/role/disclosureRef
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-Name Accounting Standards Codification
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Reference 15: http://www.xbrl.org/2003/role/disclosureRef
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Reference 16: http://www.xbrl.org/2003/role/disclosureRef
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Reference 17: http://www.xbrl.org/2003/role/disclosureRef
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Reference 18: http://www.xbrl.org/2003/role/disclosureRef
-Topic 505
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Reference 19: http://www.xbrl.org/2003/role/disclosureRef
-Topic 505
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-Section 50
-Paragraph 18
-Subparagraph (d)
-Publisher FASB
-URI https://asc.fasb.org//1943274/2147481112/505-10-50-18

+ Details

Lease - Schedule of Lease Costs and Cash Paid (Details) - USD ($) $ in Thousands	3 Months Ended
	Mar. 31, 2024	Mar. 31, 2023
Lease, Cost [Abstract]
Cash paid for operating lease liabilities	$ 640	$ 840
Operating lease costs	990	980
Variable lease costs	$ 381	$ 245

Fair Value Measurement - Summary of Investments Measured and Recognized at Fair Value (Details) - USD ($) $ in Thousands	Mar. 31, 2024	Dec. 31, 2023
Schedule Of Available For Sale Securities [Line Items]
Amortized Cost	$ 142,998	$ 174,429
Fair Value	142,998	174,429
Money Market Funds \| Level 1 \| Financial Assets Included Within Cash and Cash Equivalents
Schedule Of Available For Sale Securities [Line Items]
Amortized Cost	142,998	174,429
Fair Value	$ 142,998	$ 174,429

- Definition

Line items represent financial concepts included in a table. These concepts are used to disclose reportable information associated with domain members defined in one or many axes to the table.

+ References

Reference 1: http://www.xbrl.org/2003/role/disclosureRef
-Topic 320
-SubTopic 10
-Name Accounting Standards Codification
-Section 50
-Paragraph 2
-Publisher FASB
-URI https://asc.fasb.org//1943274/2147481800/320-10-50-2

Reference 2: http://www.xbrl.org/2003/role/disclosureRef
-Topic 320
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-Paragraph 2
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Reference 3: http://www.xbrl.org/2003/role/disclosureRef
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Reference 4: http://www.xbrl.org/2003/role/disclosureRef
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-SubTopic 10
-Name Accounting Standards Codification
-Section 50
-Paragraph 2
-Subparagraph (aaa)
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-URI https://asc.fasb.org//1943274/2147481800/320-10-50-2

Reference 5: http://www.xbrl.org/2003/role/disclosureRef
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-Name Accounting Standards Codification
-Section 50
-Paragraph 2
-Subparagraph (b)
-Publisher FASB
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Reference 6: http://www.xbrl.org/2003/role/disclosureRef
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Reference 7: http://www.xbrl.org/2003/role/disclosureRef
-Topic 320
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Reference 8: http://www.xbrl.org/2003/role/disclosureRef
-Topic 320
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-Name Accounting Standards Codification
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Reference 9: http://www.xbrl.org/2003/role/disclosureRef
-Topic 320
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-Paragraph 3
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-Publisher FASB
-URI https://asc.fasb.org//1943274/2147481800/320-10-50-3

Reference 10: http://www.xbrl.org/2003/role/disclosureRef
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Reference 11: http://www.xbrl.org/2003/role/disclosureRef
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Reference 12: http://www.xbrl.org/2003/role/disclosureRef
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-URI https://asc.fasb.org//1943274/2147481800/320-10-50-3

+ Details

Net Loss Per Share (Tables)

3 Months Ended

Mar. 31, 2024

Earnings Per Share [Abstract]

Summary of Potential Dilutive Securities Excluded from Calculation of Diluted Per Share


	March 31,
	2024		2023
Stock options, issued and outstanding		9,169,285		6,949,081
Estimated shares issuable under the employee stock purchase plan		114,511		105,062
Restricted stock, issued and outstanding		65,130		247,157
Total		9,348,926		7,301,300

Stock-Based Compensation

3 Months Ended

Mar. 31, 2024

Share-Based Payment Arrangement [Abstract]

Stock-Based Compensation

Note 7. Stock-Based Compensation

Effective January 1, 2024, the number of shares of common stock available under the 2021 Equity Incentive (the “2021 Plan”) Plan increased by 1,798,926 shares pursuant to the evergreen provision. As of March 31, 2024, 770,983 shares of common stock remained available for issuance under the 2021 Plan. Effective January 1, 2024, the number of shares of common stock available under the 2021 Employee Stock Purchase Plan (the "ESPP") increased by 359,785 shares pursuant to the evergreen provision of the ESPP. As of

March 31, 2024, 811,671 shares of common stock remained available for issuance under the ESPP. As of March 31, 2024, 1,993,000 shares of common stock remained available for issuance under the 2023 Inducement Equity Plan as adopted in November 2023.

Stock-Based Compensation Expense


	Three Months Ended
	March 31,
	2024		2023
Research and development	$	2,546	$	1,474
General and administrative		2,476		1,759
Total stock-based compensation expense	$	5,022	$	3,233

As of March 31, 2024, there was $42.9 million of total unrecognized stock-based compensation expense which is expected to be recognized over a weighted-average period of 2.6 years.

Stock Options

The following table summarizes stock option activity:


	Outstanding Options
	Shares			Weighted- Average Exercise		Weighted- Average Remaining Contractual Term (Years)
Balance, December 31, 2023		7,357,607		$	9.34		8.1
Granted		1,838,510			14.60
Exercised		(22,750	)		5.09
Cancelled		(4,082	)		9.61
Balance, March 31, 2024		9,169,285			10.40		8.3
Exercisable, March 31, 2024		4,020,182		$	9.08		7.6

Restricted Stock

The following table summarizes the restricted stock activity:


	Number of Restricted Stock Awards			Weighted-Average Grant Date Fair Value
Balance, December 31, 2023		111,920		$	4.06
Granted		—			—
Released		(44,226	)		4.03
Forfeited		(2,564	)		3.96
Balance, March 31, 2024		65,130		$	4.09

Stock-Based Compensation - Additional Information (Details) - USD ($) $ in Millions	3 Months Ended
	Mar. 31, 2024	Jan. 01, 2024
Share Based Compensation Arrangement By Share Based Payment Award [Line Items]
Total unrecognized stock-based compensation expense	$ 42.9
Unrecognized stock-based compensation expense, weighted-average period	2 years 7 months 6 days
2021 Equity Incentive Plan
Share Based Compensation Arrangement By Share Based Payment Award [Line Items]
Reserved shares of common stock to grant stock-based compensation awards	770,983
Increase in number of shares of common stock available under evergreen provision		1,798,926
2021 Employee Stock Purchase Plan
Share Based Compensation Arrangement By Share Based Payment Award [Line Items]
Reserved shares of common stock to grant stock-based compensation awards	811,671
Increase in number of shares of common stock available under evergreen provision		359,785
2023 Inducement Plan
Share Based Compensation Arrangement By Share Based Payment Award [Line Items]
Reserved shares of common stock to grant stock-based compensation awards	1,993,000

- Definition

Line items represent financial concepts included in a table. These concepts are used to disclose reportable information associated with domain members defined in one or many axes to the table.

+ References

+ Details

Summary of Significant Accounting Policies

3 Months Ended

Mar. 31, 2024

Accounting Policies [Abstract]

Summary of Significant Accounting Policies

Note 2. Summary of Significant Accounting Policies

There have been no significant changes to the significant accounting policies during the three months ended March 31, 2024, as compared to those included in the Company’s Annual Report on Form 10-K filed with the SEC on March 28, 2024.

Recent Accounting Pronouncements - Not Yet Adopted

Leases

3 Months Ended

Mar. 31, 2024

Leases [Abstract]

Leases

Note 5. Leases

Operating Leases

The Company leases its headquarters with its main offices and laboratory facilities in Redwood City and San Carlos, California, pursuant to leases which expire in 2025 and 2027, respectively. The San Carlos lease includes a renewal option for an additional five years until January 2032, which has been included in the determination of the right-of-use as of March 31, 2024.

In November 2023, the Company submitted a claim of approximately $1.5 million against tenant improvement allowance reimbursement in connection with its operating lease for lab space located at 1585 Industrial Road, San Carlos, California which was received in January 2024. Of the total reimbursement, approximately $0.4 million constitutes a loan required to be repaid in the form of additional lease payments over the remaining original lease term at an annual interest rate of 7%. Upon receipt of the reimbursement, the Company remeasured the lease liability and related right-of-use asset.

The following table summarizes the lease costs and cash paid for the Company’s leases (in thousands):


	Three Months Ended
	March 31,
	2024		2023
Cash paid for operating lease liabilities	$	640	$	840
Operating lease costs		990		980
Short-term lease cost		—		—
Variable lease costs		381		245

The maturities of lease liabilities as of March 31, 2024 were as follows (in thousands):


	Operating Lease
Year Ending December 31,	Commitments
2024 (remaining nine months)	$	3,154
2025		2,903
2026		1,525
2027		1,443
2028		1,474
Thereafter		4,827
Total future undiscounted lease payments		15,326
Less: Imputed interest		(4,234	)
Total operating lease liabilities	$	11,092
Operating lease liabilities, current		3,166
Operating lease liabilities, non-current		7,926
Total operating lease liabilities	$	11,092

Supplemental balance sheet information related to leases was as follows:


	Three Months Ended
	March 31,
	2024			2023
Weighted-average remaining lease term (in years) - operating leases		5.9			6.1
Weighted-average discount rate - operating leases		11.42	%		11.43	%

Condensed Statements of Cash Flows - USD ($) $ in Thousands	3 Months Ended
Condensed Statements of Cash Flows - USD ($) $ in Thousands	Mar. 31, 2024	Mar. 31, 2023
Operating Activities
Net loss	$ (39,061)	$ (29,051)
Adjustments to reconcile net loss to net cash used in operating activities
Depreciation expense	420	293
Non-cash operating lease expense	999	612
Stock-based compensation expense	5,022	3,233
Net amortization of premiums and accretion of discounts on investments		1
Changes in operating assets and liabilities:
Prepaid expenses and other current assets	(333)	2,345
Other assets	(1,236)	(744)
Accounts payable	(2,176)	665
Accrued expenses and other current liabilities.	3,836	(823)
Operating lease liabilities	499	(575)
Net cash used in operating activities	(32,030)	(24,044)
Investing Activities
Purchase of property and equipment	(35)	(2,906)
Maturities of investments		1,150
Net cash used in investing activities	(35)	(1,756)
Financing Activities
Proceeds from stock option exercise	116	201
Net cash provided by financing activities	116	201
Net decrease in cash, cash equivalents, and restricted cash	(31,949)	(25,599)
Cash, cash equivalents, and restricted cash at the beginning of the period	177,236	112,250
Cash, cash equivalents, and restricted cash at the end of the period	145,287	86,651
Non-cash financing and investing activities:
Acquisition of operating lease right-of-use assets		11,639
Acquisition of property and equipment in accounts payable and accrued liabilities	34	375
Reconciliation of cash and cash equivalents and restricted cash:
Cash and cash equivalents	144,918	86,300
Restricted cash	369	351
Cash, cash equivalents, and restricted cash at the end of the period	$ 145,287	$ 86,651

Balance Sheet Components - Additional Information (Details) - USD ($) $ in Thousands	3 Months Ended
	Mar. 31, 2024	Mar. 31, 2023
Balance Sheet Related Disclosures [Abstract]
Depreciation expense	$ 420	$ 293

Balance Sheet Components - Summary of Accrued Expense and Other Current Liabilities (Details) - USD ($) $ in Thousands	Mar. 31, 2024	Dec. 31, 2023
Accrued Liabilities, Current [Abstract]
Accrued research and development materials and services	$ 14,054	$ 6,952
Accrued personnel expenses	2,430	5,956
Accrued professional services	669	443
Other	226	192
Total accrued expenses and other current liabilities	$ 17,379	$ 13,543

Stock-Based Compensation - Summary of Restricted Stock Activity (Details) - Restricted Stock	3 Months Ended
	Mar. 31, 2024 $ / shares shares
Share-Based Compensation Arrangement by Share-Based Payment Award [Line Items]
Number of Restricted Stock Awards \| shares	111,920
Number of Restricted Stock Awards, Released \| shares	(44,226)
Number of Restricted Stock Awards, Forfeited \| shares	(2,564)
Number of Restricted Stock Awards \| shares	65,130
Weighted-Average Grant Date Fair Value, Beginning Balance \| $ / shares	$ 4.06
Weighted-Average Grant Date Fair Value, Released \| $ / shares	4.03
Weighted-Average Grant Date Fair Value, Forfeited \| $ / shares	3.96
Weighted-Average Grant Date Fair Value, Ending Balance \| $ / shares	$ 4.09

- Definition

Line items represent financial concepts included in a table. These concepts are used to disclose reportable information associated with domain members defined in one or many axes to the table.

+ References

+ Details

Condensed Statements of Stockholders' Equity - USD ($) $ in Thousands	Total	Common Stock	Additional Paid-In Capital	Accumulated Other Comprehensive Gain (Loss)	Accumulated Deficit
Balance at Dec. 31, 2022	$ 108,539	$ 3	$ 240,107	$ (1)	$ (131,570)
Balance (in shares) at Dec. 31, 2022		29,561,554
Exercise of stock options	407		407
Exercise of stock options, (in shares)		44,501
Issuance of restricted stock (in shares)		45,079
Stock-based compensation expense	3,233		3,233
Unrealized gain (loss) on investments, net	1			$ 1
Net loss	(29,051)				(29,051)
Balance at Mar. 31, 2023	83,129	$ 3	243,747		(160,621)
Balance (in shares) at Mar. 31, 2023		29,651,134
Balance at Dec. 31, 2023	169,237	$ 4	418,058		(248,825)
Balance (in shares) at Dec. 31, 2023		35,866,610
Exercise of stock options	$ 116		116
Exercise of stock options, (in shares)	22,750	22,750
Issuance of restricted stock (in shares)		44,226
Stock-based compensation expense	$ 5,022		5,022
Net loss	(39,061)				(39,061)
Balance at Mar. 31, 2024	$ 135,314	$ 4	$ 423,196		$ (287,886)
Balance (in shares) at Mar. 31, 2024		35,933,586

- Definition

The portion of profit or loss for the period, net of income taxes, which is attributable to the parent.

+ References

Reference 1: http://www.xbrl.org/2003/role/disclosureRef
-Topic 235
-SubTopic 10
-Name Accounting Standards Codification
-Section S99
-Paragraph 1
-Subparagraph (SX 210.4-08(g)(1)(ii))
-Publisher FASB
-URI https://asc.fasb.org//1943274/2147480678/235-10-S99-1

Reference 2: http://www.xbrl.org/2003/role/disclosureRef
-Topic 323
-SubTopic 10
-Name Accounting Standards Codification
-Section 50
-Paragraph 3
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+ Details

- Definition

Amount of equity (deficit) attributable to parent. Excludes temporary equity and equity attributable to noncontrolling interest.

+ References

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+ Details

Leases - Schedule of Supplemental Balance Sheet Information Related to Leases (Details)	Mar. 31, 2024	Mar. 31, 2023
Lease, Cost [Abstract]
Weighted-average remaining lease term (in years) - operating leases	5 years 10 months 24 days	6 years 1 month 6 days
Weighted-average discount rate - operating leases	11.42%	11.43%

Fair Value Measurement (Tables)

3 Months Ended

Mar. 31, 2024

Fair Value Disclosures [Abstract]

Summary of Investments Measured and Recognized at Fair Value


		March 31, 2024
	Fair Value Hierarchy Level	Amortized Cost		Gross Unrealized Gains		Gross Unrealized Losses		Fair Value
Financial assets included in cash and cash equivalents:
Money market funds	Level 1	$	142,998	$	—	$	—	$	142,998
Total		$	142,998	$	—	$	—	$	142,998


		December 31, 2023
	Fair Value Hierarchy Level	Amortized Cost		Gross Unrealized Gains		Gross Unrealized Losses		Fair Value
Financial assets included in cash and cash equivalents:
Money market funds	Level 1	$	174,429	$	—	$	—	$	174,429
Total		$	174,429	$	—	$	—	$	174,429

Balance Sheet Components

3 Months Ended

Mar. 31, 2024

Balance Sheet Related Disclosures [Abstract]

Balance Sheet Components

Note 4. Balance Sheet Components

Property and Equipment, Net

Property and equipment, net consists of the following (in thousands):


	March 31,			December 31,
	2024			2023
Laboratory equipment	$	3,902		$	3,852
Leasehold improvements		3,195			3,195
Computer equipment		146			130
Furniture and fixtures		409			409
Construction in progress		6			4
Total property and equipment, gross		7,658			7,590
Less: accumulated depreciation		(2,852	)		(2,431	)
Total property and equipment, net	$	4,806		$	5,159

Depreciation expense for the three months ended March 31, 2024 was $0.4 million. Depreciation expense for the three months ended March 31, 2023 was $0.3 million.

Accrued Expenses and Other Current Liabilities

Accrued expenses and other current liabilities consisted of the following (in thousands):


	March 31,		December 31,
	2024		2023
Accrued research and development materials and services	$	14,054	$	6,952
Accrued personnel expenses		2,430		5,956
Accrued professional services		669		443
Other		226		192
Total accrued expenses and other current liabilities	$	17,379	$	13,543

Balance Sheet Components - Summary of Property and Equipment, Net (Details) - USD ($) $ in Thousands	Mar. 31, 2024	Dec. 31, 2023
Property, Plant and Equipment [Line Items]
Total property and equipment, gross	$ 7,658	$ 7,590
Less: accumulated depreciation	(2,852)	(2,431)
Total property and equipment, net	4,806	5,159
Laboratory Equipment
Property, Plant and Equipment [Line Items]
Total property and equipment, gross	3,902	3,852
Leasehold Improvements
Property, Plant and Equipment [Line Items]
Total property and equipment, gross	3,195	3,195
Computer Equipment
Property, Plant and Equipment [Line Items]
Total property and equipment, gross	146	130
Furniture and Fixtures
Property, Plant and Equipment [Line Items]
Total property and equipment, gross	409	409
Construction in Progress
Property, Plant and Equipment [Line Items]
Total property and equipment, gross	$ 6	$ 4

Document and Entity Information - shares	3 Months Ended
Document and Entity Information - shares	Mar. 31, 2024	Apr. 26, 2024
Cover [Abstract]
Document Type	10-Q
Amendment Flag	false
Document Period End Date	Mar. 31, 2024
Document Fiscal Year Focus	2024
Document Fiscal Period Focus	Q1
Document Quarterly Report	true
Document Transition Report	false
Entity Registrant Name	Biomea Fusion, Inc.
Entity Central Index Key	0001840439
Current Fiscal Year End Date	--12-31
Entity Filer Category	Non-accelerated Filer
Trading Symbol	BMEA
Entity Emerging Growth Company	true
Entity Ex Transition Period	false
Entity Small Business	true
Entity Common Stock, Shares Outstanding		35,944,584
Entity Interactive Data Current	Yes
Title of 12(b) Security	Common Stock, $0.0001 par value
Security Exchange Name	NASDAQ
Entity Current Reporting Status	Yes
Entity Shell Company	false
Entity File Number	001-40335
Entity Incorporation, State or Country Code	DE
Entity Tax Identification Number	82-2520134
Entity Address, Address Line One	900 Middlefield Road, 4th Floor
Entity Address, City or Town	Redwood City
Entity Address, State or Province	CA
Entity Address, Postal Zip Code	94063
City Area Code	650
Local Phone Number	980-9099

Stock-Based Compensation - Summary of Stock Option Activity (Details) - $ / shares	3 Months Ended	12 Months Ended
	Mar. 31, 2024	Dec. 31, 2023
Share-Based Payment Arrangement [Abstract]
Shares, Beginning Balance	7,357,607
Shares, Granted	1,838,510
Shares, Exercised	(22,750)
Shares, Cancelled	(4,082)
Shares, Ending Balance	9,169,285	7,357,607
Shares, Exercisable	4,020,182
Weighted Average Exercise Price, Beginning Balance	$ 9.34
Weighted Average Exercise Price, Granted	14.6
Weighted Average Exercise Price, Exercised	5.09
Weighted Average Exercise Price, Cancelled	9.61
Weighted Average Exercise Price, Ending Balance	10.4	$ 9.34
Weighted Average Exercise, Exercisable	$ 9.08
Weighted Average Remaining Contract Term	8 years 3 months 18 days	8 years 1 month 6 days
Weighted Average Remaining Contract Term, Exercisable	7 years 7 months 6 days

Condensed Balance Sheets - USD ($) $ in Thousands	Mar. 31, 2024	Dec. 31, 2023
Current assets:
Cash and cash equivalents	$ 144,918	$ 176,866
Prepaid expenses and other current assets	2,648	2,315
Total current assets	147,566	179,181
Property and equipment, net	4,806	5,159
Operating lease right-of-use assets	9,013	9,714
Restricted cash	369	370
Other assets	6,740	5,503
Total assets	168,494	199,927
Current liabilities:
Accounts payable	4,709	6,851
Accrued expenses and other current liabilities	17,379	13,543
Operating lease liabilities, current	3,166	2,466
Total current liabilities	25,254	22,860
Operating lease liabilities, non-current	7,926	7,830
Total liabilities	33,180	30,690
Commitments and contingencies (Note 8)
Stockholders' equity
Preferred stock, $0.0001 par value; 10,000,000 authorized as of March 31, 2024 and December 31, 2023; 0 shares issued and outstanding as of March 31,2024 and December 31, 2023
Common stock, $0.0001 par value; 300,000,000 shares authorized as of March 31, 2024 and December 31, 2023; 35,933,586 and 35,866,610 shares issued and outstanding as of March 31, 2024 and December 31, 2023, respectively	4	4
Additional paid-in capital	423,196	418,058
Accumulated deficit	(287,886)	(248,825)
Total stockholders' equity	135,314	169,237
Total liabilities and stockholders' equity	$ 168,494	$ 199,927